- myNEO Therapeutics to focus on building proprietary product pipeline based on a novel class of shared therapeutic cancer targets derived from the dark genome named “camyotopes”
- Lead product CAMYO-01 incorporates a pool of colorectal cancer-specific camyotopes formulated into an mRNA-based vaccine
- CAMYO-01 is advancing towards clinical development for the treatment of colorectal cancer
Since the company was founded in 2018, it has developed and patented proprietary Artificial Intelligence (AI) algorithms that are state-of-the art in identifying novel cancer antigens, allowing optimal selection of the best cancer targets for use in immunotherapies. Building on this deep knowledge, internal research efforts have revealed a novel class of lncRNA-derived “dark genome” antigens which myNEO Therapeutics has named “camyotopes”. These tumor-derived epitopes originate from the non-coding part of the genome, or dark genome, which is increasingly associated with a variety of diseases including cancer. Preclinical validation of these targets has reinforced the company’s belief that camyotopes are a potentially game changing class of tumor antigens for cancer immunotherapy for the many patients currently lacking sufficient actionable immunogenic targets.
Following the discovery and validation of a number of camyotopes, myNEO Therapeutics has made rapid progress in advancing its first therapeutic product, CAMYO-01, towards the clinic. CAMYO-01 incorporates a pool of colorectal cancer-specific camyotopes formulated into an mRNA-based vaccine.
myNEO Therapeutics is currently performing additional pre-clinical validation experiments to prepare for the first phase of clinical development for CAMYO-01, which is expected to start before the end of 2024.
Cedric Bogaert, co-founder and CEO of myNEO Therapeutics commented: “ This evolution of our corporate identity to myNEO Therapeutics marks a pivotal milestone in our strategic development and illustrates the significant progress we are making in realizing our vision. CAMYO-01 is only the start of our plan to develop a robust pipeline of therapeutic cancer vaccines based on our unique technology platform and insights into the dark genome which we believe can unlock the future of cancer immunotherapy for the benefit of a broad population of patients. “
About myNEO Therapeutics
myNEO Therapeutics is a biopharmaceutical company focusing on the development of breakthrough therapeutic cancer vaccines by applying cutting edge AI technology to identify and validate novel cancer targets. The company’s ImmunoEngine discovery platform is empowered by proprietary data analysis tools that allow rapid screening of immuno-genomic information from cancer patients. By focusing on the complete genome of patients myNEO Therapeutics is able to identify impactful tumor alterations and previously unknown neoantigen targets from the untapped “dark genome” regions, from which it aims to develop novel cancer immunotherapeutics.
myNEO Therapeutics was founded in 2018 by leading biotech entrepreneurs Cedric Bogaert, Professor Wim Van Criekinge and Jan Van den Berghe. Mark Vaeck, founder, and former CEO of biopharmaceutical company Ablynx is chairman of the Board of Directors and Bert Coessens, founder of Cartagenia (which was acquired by Agilent Technologies), is myNEO Therapeutics Chief Operating Officer.