was founded at the faculty of bioengineering in fall 2002 as bioinformatics evolved from a service discipline that merely assisted the lab to a central core asset. This transition requires a multidisciplinary approach where people are trained with a strong formal background in both applied sciences, informatics and math/statistics. The core competences of BIOBIX are data-integration and analysis, particularly in combination with high-throughput applications. Based on these competences, BIOBIX obtained ample expertise in epigenetic research, more specifically DNA-methylation and telomere length profiling, but also histone modification and non-coding RNA analyses. Within BIOBIX there is a general focus on systems biology and comparative genomics reflected in different supported technologies: next-generation sequencing, NMR-based metabonomics, MS-based proteomics, proteogenomics, transcriptomics, phylogenetic footprinting, heterogenous data-integration statistics, ncRNA detection and target prediction, selection of novel targets. These technologies are applied in many different disease areas, but with cancer and (cardiovascular) aging as two most important targets. BIOBIX also extensive IT knowledge in setting up high performance computer environments and is one of the few European labs actively mirroring all available sequence data on dedicated hardware using in-house software.